Ursodiol

(ur-soe-dye-ole)

Other names for this medication: Ursodeoxycholic Acid (UDCA); Actigall, Urso 250, Urso Forte

•Used to treat liver, pancreatic, and gallbladder problems

•Works best when given with food. Giving with food can also help mask its bitter taste.

•Do not give at the same time as antacids containing aluminum.

•Usually well tolerated, but the most common side effect is diarrhea.

Description

•Bile acid

‐Protects the liver and increases flow of bile

‐Decreases the production and absorption of cholesterol

•Available as oral tablets and capsules

Uses

This medication is not FDA-approved specifically for animals, but it is approved for use in humans. At the discretion of your veterinarian, this medication may be used in other species (extra-label), such as for treatment of:

•Slow bile flow (cholestasis) in dogs and cats

•Biliary sludge in dogs

•Bile system inflammation in cats

•Liver inflammation in dogs

Before this medication is given

No medication is 100% safe in all patients. Discuss with your veterinarian:

•Any other medications or supplements your animal is taking

•Any conditions or diseases your animal currently has or has had in the past

•Any side effects your animal has had to medications in the past

•The risks of using this medication if your animal is pregnant or nursing

Warnings for animals

Do not use in:

•Animals that are allergic to this medication

•Animals with a complete bile duct blockage

•Rabbits, guinea pigs, or rodents

Use with caution in animals with:

•Bile duct system inflammation (cholangitis)

•Bile duct system, gallbladder, and liver inflammation (cholangiohepatitis)

•Complications related to gallstones

Certain medications are not allowed in some animal competitions. Check rules and regulations when your animal is taking a medication.

Warnings for humans

•Wash your hands after handling any medication.

How do I give this medication?

•Give with food.

‐This medication works best when given with food.

‐Food may also help mask the bitter taste of the medication and help decrease nausea.

•Do not give at the same time as antacids containing aluminum.

Give exactly as your veterinarian has prescribed. Always follow the instructions on the prescription label.

Side effects

Common – contact your veterinarian if any of these signs are severe, continue to occur, or worsen over time:

•Diarrhea

•Drooling or decreased appetite, which may be signs of nausea

Severe – stop the medication and contact your veterinarian immediately if you notice any of these signs:

•Low energy level or weakness

•Yellowing of the skin, whites of the eyes, or gums (jaundice)

How will I know it's working?

•You will not be able to see the effects of this medication.

•Your veterinarian will need to run follow-up tests to determine how well it is working.

How long will the medication effects last?

•The effect of this medication may last for a few days after the last dose.

How long do I give it for?

This medication can be given for different lengths of time. Give it for as long as your veterinarian tells you. You may need to refill the prescription.

Overdose

If you witness or suspect an overdose, call your veterinarian or an animal-specific poison control center (consultation fee applies):

•ASPCA Animal Poison Control Center: (888) 426-4435

•Pet Poison Helpline: (855) 764-7661

Have the product or label with you if possible.

Missed dose

In most cases, if you miss a dose:

•Give it when you remember, then return to the regular dosing schedule.

If it is close to the time for the next dose:

•Skip the missed dose.

•Give the next dose at the next scheduled time.

•Continue the regular dosing schedule.

If you are unsure, call your veterinary clinic. Do not double-up or give extra doses.

Storage

•Store in the original container at room temperature.

•Keep out of reach of children and animals.

Disposal

Do not flush this medication down the toilet or wash it down the sink. Options for disposing of unused or expired medications include:

•Drug-take back sites: This is preferred whenever possible. To find a site near you, contact your local law enforcement or waste management authorities.

•Home disposal: Mix the medication in with coffee grounds or kitty litter, seal in a plastic bag, and throw away in the trash.

Do not save leftover medication or give it to others to use.